PHARMACOLOGICAL REGULATION OF BLOOD-GLUCOSE LEVELS IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS

Non-insulin-dependent diabetes mellitus is a metabolic disease that is common and is characterized by insulin insufficiency and resistance. Measures such as body weight reduction and exercise improve the metabo lic defects, but pharmacological therapy is the most frequently used a nd successful therapy. The sulphonylureas stimulate insulin secretion. Metformin and troglitazone increase disposal and decrease hepatic glu cose output without causing hypoglycemia. Acarbose is a dietary aid th at spreads the dietary carbohydrate challenge to endogenous insulin oa r time. These pharmacological agents, either alone or in combination, can improve blood glucose regulation in patients with non-insulin-depe ndent diabetes mellitus.