PREPARATION AND STERIC STRUCTURES OF SATURATED OR PARTIALLY SATURATEDCYCLOPENTANE[B]PYRROLO[1,2-A][3,1]BENZOXAZINE AND CYCLOHEXANE[B]PYRROLO[1,2-A][3,1]BENZOXAZINE ISOMERS [1]

The reactions of 2-ethoxycarbonylmethyleyclopentanone (1) with cis-(3a ) and trans-2-hydroxymethylcyclohex-4-enyl-1-amine (3b) and of 2-ethox ycarbonylmethylcyclohexanone (2) with stereoisomeric 2-hydroxymethyl-1 -cyclohexylamines (4a,b) yield the isomeric cyclopentane-(5a,b) and cy clohexane[b] pyrrolo[1,2-a][3,1]benzoxazinones (6a,b) with unsaturated (5) or saturated (6) ring A, The steric structures were elucidated by means H-1, C-13 NMR and X-ray measurements. (C) 1998 Elsevier Science B.V.