VISNA VIRUS DUTPASE IS DISPENSABLE FOR NEUROPATHOGENICITY

Authors
PETURSSON G TURELLI P MATTHIASDOTTIR S GEORGSSON G ANDRESSON OS TORSTEINSDOTTIR S VIGNE R ANDRESDOTTIR V GUNNARSSON E AGNARSDOTTIR G QUERAT G
Citation
G. Petursson et al., VISNA VIRUS DUTPASE IS DISPENSABLE FOR NEUROPATHOGENICITY, Journal of virology, 72(2), 1998, pp. 1657-1661
Citations number
32
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
72
Issue
2
Year of publication
1998
Pages
1657 - 1661
Database
ISI
SICI code
0022-538X(1998)72:2<1657:VVDIDF>2.0.ZU;2-W
Abstract
The major part of the dUTPase-encoding region of the visna virus genom e was deleted. Intracerebral injection of the mutant virus resulted in a somewhat reduced viral load compared to that resulting from injecti on of the wild type, especially in the lungs, but the neuropathogenic effects were comparable. The dUTPase gene is dispensable for induction of lesions in the brain.