A wide spectrum of disease processes involve the ischiorectal fossa, i
ncluding congenital and developmental lesions; inflammatory, traumatic
, and hemorrhagic conditions; primary tumors; and pathologic processes
outside the ischiorectal fossa with secondary involvement. Both compu
ted tomography (CT) and magnetic resonance (MR) imaging are useful in
the definitive diagnosis of these pathologic conditions, with MR imagi
ng being the modality of choice because of its superior contrast resol
ution and multiplanar capability. In Gartner duct cyst, both CT and MR
imaging demonstrate a well-defined, round mass; in tailgut cyst, CT d
emonstrates a well-defined retrorectal mass with a solid or cystic app
earance. MR imaging in particular plays a major role in the assessment
of fistula in ano, infection, and hematoma. Lipoma and pelvic plexifo
rm neurofibroma typically have low attenuation and high signal intensi
ty at CT and MR imaging, respectively. Recurrent rectal tumor appears
at both modalities as an irregular soft-tissue mass with or without ce
ntral necrosis in the presacral space, perineum, or pelvic sidewall. F
amiliarity with the imaging features and differential diagnoses of var
ious ischiorectal pathologic processes will facilitate prompt, accurat
e diagnosis and treatment.