An outbreak of hepatogenous photosensitisation occurred in fallow deer
and was diagnosed as facial eczema on the basis of liver lesions and
plasma enzyme changes over 56 weeks. Clinical signs of photosensitisat
ion were not as obvious as they are in sheep and cattle. The condition
occurred over autumn and in the following spring. Six of 23 deer died
or were destroyed. Concentrations of plasma total bilirubin, total bi
le acids and cholesterol increased, as well as the activities of aspar
tate transaminase, glutamic dehydrogenase, lactic dehydrogenase, alkal
ine phosphatase and gamma glutamyltransferase. Albumin:globulin ratios
declined due to moderate increases in globulin and minor reductions i
n albumin. Many of the plasma enzyme activities did not return to norm
al after autumn and increased to even higher values during the spring
outbreak of photosensitisation. Minor plasma biochemical changes were
also detected in non-photosensitive deer in the same herd.