Jc. Lien et al., SYNTHESIS AND ANTIPLATELET, ANTIINFLAMMATORY, AND ANTIALLERGIC ACTIVITIES OF 2-SUBSTITUTED 3-CHLORO-1,4-NAPHTHOQUINONE DERIVATIVES, Bioorganic & medicinal chemistry, 5(12), 1997, pp. 2111-2120
A series of 2-substituted 3-chloro-1,4-naphthoquinones was synthesized
, and the antiplatelet, antiinflammatory, and antiallergic activities
of these compounds were evaluated. The structure-activity relationship
s in this series were also examined. Most of the 2-alkyl/arylcarboxami
do derivatives of 3-chloro-1,4-naphthoquinone showed potent activities
with similar trends in each of the activities evaluated. (C) 1997 Els
evier Science Ltd.