SYNTHESIS AND ANTIPLATELET, ANTIINFLAMMATORY, AND ANTIALLERGIC ACTIVITIES OF 2-SUBSTITUTED 3-CHLORO-1,4-NAPHTHOQUINONE DERIVATIVES

Citation
Jc. Lien et al., SYNTHESIS AND ANTIPLATELET, ANTIINFLAMMATORY, AND ANTIALLERGIC ACTIVITIES OF 2-SUBSTITUTED 3-CHLORO-1,4-NAPHTHOQUINONE DERIVATIVES, Bioorganic & medicinal chemistry, 5(12), 1997, pp. 2111-2120
Citations number
10
ISSN journal
09680896
Volume
5
Issue
12
Year of publication
1997
Pages
2111 - 2120
Database
ISI
SICI code
0968-0896(1997)5:12<2111:SAAAAA>2.0.ZU;2-V
Abstract
A series of 2-substituted 3-chloro-1,4-naphthoquinones was synthesized , and the antiplatelet, antiinflammatory, and antiallergic activities of these compounds were evaluated. The structure-activity relationship s in this series were also examined. Most of the 2-alkyl/arylcarboxami do derivatives of 3-chloro-1,4-naphthoquinone showed potent activities with similar trends in each of the activities evaluated. (C) 1997 Els evier Science Ltd.