DIHYDRO-6,7-DICHLORO-PYRIDO[2,3-B]PYRAZINE-8-OXIDE AS SELECTIVE GLYCINE ANTAGONIST WITH IN-VIVO ACTIVITY

Authors
MICHELI F CUGOLA A DONATI D MISSIO A PECUNIOSO A REGGIANI A TARZIA G
Citation
F. Micheli et al., DIHYDRO-6,7-DICHLORO-PYRIDO[2,3-B]PYRAZINE-8-OXIDE AS SELECTIVE GLYCINE ANTAGONIST WITH IN-VIVO ACTIVITY, Bioorganic & medicinal chemistry, 5(12), 1997, pp. 2129-2132
Citations number
18
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
5
Issue
12
Year of publication
1997
Pages
2129 - 2132
Database
ISI
SICI code
0968-0896(1997)5:12<2129:DASG>2.0.ZU;2-2
Abstract
Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnin e insensitive glycine binding site on the NMDA receptor revealing it t o be a useful tool to evaluate the effectiveness of glycine antagonist s in vivo. (C) 1997 Elsevier Science Ltd.