CROSS-REACTIVITIES OF HUMAN AND SOME ARTIODACTYLA HAPTOGLOBINS

Cross reactivities among human and wild hoofed mammalian haptoglobins were studied by previously characterized monoclonal anti-human haptogl obin antibody, clone 2.36.71.41. Haptoglobins present in serum of most animals, members of Bovidae and Cervidae families, were recognized by monoclonal anti-human haptoglobin antibody in ELISA. Moreover, Bovida e and Cervidae haptoglobins, like human haptoglobin type 2-2, formed v isible precipitates in agarose gel. Monoclonal antibody anti-human hap toglobin, clone 2.36.71.41 reacted with highly conserved immunological determinant present an human type 2-2 and on Bovidae and Cervidae hap toglobin molecules. Monoclonal antibody 2.36.71.41 could be considered as an excellent reagent used in veterinary diagnosis for fast discove ry of some inflammatory diseases of wild and domestic Artiodactyla.