CONSTRUCTION AND CHARACTERIZATION OF A HELICOBACTER-PYLORI CLPB MUTANT AND ROLE OF THE GENE IN THE STRESS-RESPONSE

Authors
ALLAN E MULLANY P TABAQCHALI S
Citation
E. Allan et al., CONSTRUCTION AND CHARACTERIZATION OF A HELICOBACTER-PYLORI CLPB MUTANT AND ROLE OF THE GENE IN THE STRESS-RESPONSE, Journal of bacteriology, 180(2), 1998, pp. 426-429
Citations number
28
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
180
Issue
2
Year of publication
1998
Pages
426 - 429
Database
ISI
SICI code
0021-9193(1998)180:2<426:CACOAH>2.0.ZU;2-C
Abstract
Antiserum raised against whole Helicobacter pylori cells identified a novel 94-kDa antigen. The nucleotide sequence of the gene encoding the 94-kDa antigen was determined, and analysis of the deduced amino acid sequence revealed structural features typical of the ClpB ATPase fami ly of stress response proteins. An isogenic H. pylori clpB mutant show ed increased sensitivity to high-temperature stress, indicating that t he clpB gene product functions as a stress response protein in H. pylo ri.