MOLECULAR PATHOGENESIS OF THEILERS MURINE ENCEPHALOMYELITIS VIRUS-INDUCED DEMYELINATING DISEASE IN MICE

Citation
Hl. Lipton et Ml. Jelachich, MOLECULAR PATHOGENESIS OF THEILERS MURINE ENCEPHALOMYELITIS VIRUS-INDUCED DEMYELINATING DISEASE IN MICE, Intervirology, 40(2-3), 1997, pp. 143-152
Citations number
67
Categorie Soggetti
Virology
Journal title
ISSN journal
03005526
Volume
40
Issue
2-3
Year of publication
1997
Pages
143 - 152
Database
ISI
SICI code
0300-5526(1997)40:2-3<143:MPOTME>2.0.ZU;2-Y
Abstract
After an acute phase of virus growth in neurons (e.g. anterior horn ce lls), Theiler's murine encephalomyelitis virus (TMEV) persists as a ch ronic productive infection, largely in macrophages in the CNS white ma tter. TMEV replication in macrophages is highly restricted, probably a s the result of host cell factors. The preponderance of evidence indic ates that TMEV persistence leads to immunopathologic damage of myelin, mediated by major histocompatibility class II-restricted Th1 lymphocy tes directed at a virus epitope(s) rather than host neuroantigens at l east early in the infection. Analysis of TMEV recombinant and mutant v iruses suggests that persistence requires a specific capsid conformati on involving the VP2 puff and VP1 loops, which may influence persisten ce through virion receptor binding or attachment to host cells, e.g. m acrophages.