IN-VITRO SUSCEPTIBILITY OF CHLAMYDIA-PECORUM TO MACROLIDES, TETRACYCLINES, QUINOLONES AND BETA-LACTAM

The in vitro susceptibility of Chlamydia pecorum to two macrolides (cl arithromycin and erythromycin), two tetracyclines (doxycycline and min ocycline), two quinolones (ofloxacin and ciprofloxacin) and one beta-l actam (ampicillin) was determined. The MICs were 0.004 to 0.008 mu g/m l for clarithromycin, 0.008 to 0.031 mu g/ml for doxycycline and minoc ycline, 0.063 to 0.125 mu g/ml for erythromycin, 0.25 to 0.5 mu g/ml f or ofloxacin and 0.25 to 1.0 mu g/ml for ciprofloxacin. The MIC for am picillin was greater than 1,024 mu g/ml. The results show clarithromyc in and doxycycline are the two most effective drugs against C. pecorum .