ACUTE TOXICITY OF THE MYCOTOXIN RORIDIN-E ON LIVER AND KIDNEY OF RATS

The effect of in vivo exposure to roridin E alone and in combination w ith linoleic acid on rats was studied. Male rats treated with a sublet hal dose (2 mg/kg body weight) of the trichothecene roridin E showed a significant increase in glucose-6-phosphatase of liver Whereas, rats treated with roridin E plus linoleic acid (300 mu mol/kg body weight) showed a significant decrease in the blood glucose and glutathione lev els. The combined effect also resulted in a significant decrease in th e levels of superoxide dismutase and glucose-6-phosphatase in the kidn ey together with a significant increase in the lipid peroxidation (TEA RS) in the liver. In conclusion, treatment of rats by sublethal dose o f roridin E alone did not caused any significant effect. However, co-a dministration of linoleic acid with roridin E resulted in increasing i ts toxicity.