DNA-REPAIR - PARP - ANOTHER GUARDIAN ANGEL

Authors
JEGGO PA
Citation
Pa. Jeggo, DNA-REPAIR - PARP - ANOTHER GUARDIAN ANGEL, Current biology, 8(2), 1997, pp. 49-51
Citations number
20
Journal title
Current biology → ACNP
ISSN journal
09609822
Volume
8
Issue
2
Year of publication
1997
Pages
49 - 51
Database
ISI
SICI code
0960-9822(1997)8:2<49:D-P-AG>2.0.ZU;2-8
Abstract
Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) ha ve elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage.