TAZOBACTAM-PIPERACILLIN COMPARED WITH SULBACTAM-AMPICILLIN, CLAVULANIC ACID-TICARCILLIN, SULBACTAM-CEFOPERAZONE, AND PIPERACILLIN FOR ACTIVITY AGAINST BETA-LACTAMASE-PRODUCING BACTERIA ISOLATED FROM PATIENTS WITH COMPLICATED URINARY-TRACT INFECTIONS

The antibacterial activity of tazobactam-piperacillin was compared wit h that of sulbactam-ampicillin, clavulanic acid-ticarcillin, sulbactam -cefoperazone and piperacillin against beta-lactamase-producing bacter ia isolated from patients with complicated urinary tract infections. T azobactam-piperacillin showed a broad antibacterial spectrum against gram-negative and gram-positive bacteria. The minimum inhibitory conce ntrations (MIC90) of tazobactam-piperacillin were 6.25 mu g/ml against Escherichia coli, 1.56 mu g/ml against Proteus mirabilis, 3.13 mu g/m l against Proteus vulgaris, 6.25 mu g/ml against methicillin-susceptib le Staphylococcus aureus and 6.25 mu g/ml coagulase-negative methicill in-susceptible staphylococci. Against all beta-lactamase-producing bac teria tested the antibacterial activity of tazobactam-piperacillin was at least 4- to 64-fold stronger than that of piperacillin, clavulanic acid-ticarcillin, and sulbactamampicillin, and similar to or greater than that of sulbactam-cefoperazone except for E. coli.