INSOLUBLE GLYCOGEN, A METABOLIZABLE INTERNAL ADSORBENT, DECREASES THELETHALITY OF ENDOTOXIN-SHOCK IN RATS

Insoluble glycogen is an enzymatically modified form of naturally occu rring soluble glycogen with a great adsorbing capacity. It can be meta bolized by phagocytes to glucose. In this study we used insoluble glyc ogen intravenously in the experimental endotoxin shock of rats, Wistar male rats were sensitized to endotoxin by Pb acetate. The survival of rats were compared in groups of animals endotoxin shock treated and n on-treated with insoluble glycogen. Furthermore, we have determined in vitro the binding capacity of insoluble glycogen for endotoxin, tumou r necrosis factor alpha, interleukin-l and secretable phospholipase A( 2)., Use of 10 mg/kg dose of insoluble glycogen could completely preve nt the lethality of shock induced by LD50, quantity of endotoxin in ra ts. All animals treated survived, Insoluble glycogen is a form of 'met abolizable internal adsorbents'. It can potentially be used for treatm ent of septic shock.