ALLELE LOSSES IN THE SHORT ARM OF HUMAN-CHROMOSOME 3 RELATED TO RENAL, UTERINE, AND OVARIAN-CARCINOMA - A STUDY WITH TRI-NUCLEOTIDE AND TETRANUCLEOTIDE MARKERS

Seven highly informative tri-and tetrameric microsatellite markers of the human chromosome 3 covering 3p13-p22 and 3p25 regions known to be frequently deleted in various solid tumors were selected from the Coop erative Human Linkage Center data bank. The loss of heterozygosity was detected in 7 out of 20 renal cell carcinomas, 1 out of the 6 ovarian tumors, and 2 out of 14 uterine adenocarcinomas. Some renal carcinoma s showed multiple deletions among regions of retained heterozygosity. Markers GATA7A01 (4/14), GGAT2G03 (4/14), and ATA10H11 (3/7) were foun d informative for these studies.