DETECTION AND CHARACTERIZATION OF HUMAN-CHROMOSOME-19 SEQUENCES PARTLY SIMILAR WITH HIV-1 REGULATORY GENES TAT REV/

Sequences partly homologous to the first translated exon of the overla pping tat and rev regulatory genes of the human immunodeficiency virus type 1 (HIV-1) were detected in the human genome by hybridization und er mild conditions. The tat/rev-like sequences of human chromosome 19 were cloned and analyzed. In some cases tat/rev-like genomic elements appeared to be adjacent. A number of sequences showing 50-65% homology with one of the cloned tat/rev-like elements were revealed in gene ba nks. Most homologous regions are at the 5' or 3' untranslated gene reg ions in various organisms, from primitive eukaryotes to humans. In tot al, hybridization under mild conditions revealed approximately a dozen tat/rev-like elements on chromosome 19 and 500-1000 elements in the w hole human genome.