Aj. Adamson et al., ONE-POT SYNTHESIS OF 1,2,3,4-TETRAFLUOROACRIDINES FROM PENTAFLUOROBENZALDEHYDE, Journal of chemical research. Synopses, (3), 1997, pp. 76-77
1,2,3,4-Tetrafluoroacridines (accompanied in certain cases by their 3-
arylamino derivatives) have been prepared in one-pot fashion (via form
ation in situ of the corresponding Schiff bases) by heating pentafluor
obenzaldehyde with a 2 molar equivalence of aniline, para-substituted
anilines 4-RC6H4NH2 (R = OMe, Me, Bu-t, F, Cl, Br) or 3,5-dimethylanil
ine in boiling o-dichlorobenzene.