ANTIFUNGAL EFFECTS OF NEW HETEROCYCLIC-COMPOUNDS, 6H-PYRIMIDO[2,1-A]ISOINDOLE DERIVATIVES

Authors
NESMERAK K PELOUCHOVA H VSETECKA V NEMEC I GABRIEL J
Citation
K. Nesmerak et al., ANTIFUNGAL EFFECTS OF NEW HETEROCYCLIC-COMPOUNDS, 6H-PYRIMIDO[2,1-A]ISOINDOLE DERIVATIVES, Folia microbiologica, 43(1), 1998, pp. 39-41
Citations number
11
Categorie Soggetti
Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Folia microbiologica → ACNP
ISSN journal
00155632
Volume
43
Issue
1
Year of publication
1998
Pages
39 - 41
Database
ISI
SICI code
0015-5632(1998)43:1<39:AEONH6>2.0.ZU;2-L
Abstract
Minimal inhibitory concentrations for 10 new condensed isoindole deriv atives were established by the agar diffusion method. Benzo[b]-6H-pyri mido[2,1a]isoindole-4-one exhibited a broad antifungal effect; the obs erved MIC (mg/L) were 7 (K. lactis), 8 (C. pseudotropicalis), 17 (W. f luorescens), 22 (E. magnusii), 31 (P. membranaefaciens), 32 (S. alluvi us) and 32 (S. cerevisiae). The compound also inhibited the growth of B. subtilis (MIC 9 mg/L). No effect on the growth of E. coli was found .