ANTIBACTERIAL EFFECTS OF SOME 1-SUBSTITUTED 1,2,4-TRIAZOLES

Seventeen synthetic 1-substituted 1,2,4-triazoles exerted a significan t effect on the bacteria B.subtilis, S. aureus, E. coli and P. aerugin osa. The least sensitive to the effects of the triazoles was S. aureus . With all triazole derivatives and their combinations, B. subtilis an d P. aeruginosa exhibited IC50 and MIC values several times higher tha n with ampicillin. The most effective triazoles have a N-phenyl ring o r benzimidinoyl ring substituted with one or several chlorine atoms. T he highest tested concentration of the three most effective triazoles influenced the specific growth rate.