SJOGRENS-SYNDROME WITH ANTICENTROMERE ANTIBODIES

Clinical and laboratory findings in 10 women with Sjogren's syndrome a nd positive anticentromere antibodies were compared to those in 50 pat ients with Sjogren's syndrome and typical serologic features, The anti centromere antibody-positive patients were more likely to have Raynaud 's phenomenon and less likely to have leukopenia polyclonal hypergamma globulinemia, rheumatoid factor, and anti-SSA/Ro antibody, Four antice ntromere antibody-positive patients developed limited cutaneous sclero derma during follow-up, but none had lymphoma; some of the other patie nts in this group exhibited stable symptoms typical for Sjogren's synd rome, Among our overall population of Sjogren's syndrome patients who met diagnostic criteria for primary Sjogren's syndrome at the first ev aluation, 16.6% tested positive for anticentromere antibodies.