G. Dziewczapolski et al., OPPOSITE ROLES OF D1 AND D5 DOPAMINE-RECEPTORS IN LOCOMOTION REVEALEDBY SELECTIVE ANTISENSE OLIGONUCLEOTIDES, NeuroReport, 9(1), 1998, pp. 1-5
CONTRALATERAL rotations induced by the D1-like agonist SKF 38393 in un
ilaterally 6-hydroxydopamine-lesioned rats were completely prevented b
y the administration of the D1-like antagonist SCH 23390. A similar re
sult was obtained after intracerebroventricular administration of an a
ntisense oligodeoxynucleotide for the D1 receptor (D1R-as). Contrariwi
se, administration of a D5R-as potentiated the effects of SKF 38393, s
howing a 60% increase in the rotational scores. Both effects were reve
rsible upon cessation of D1R-as or DSR-as treatment and were also spec
ific since rotational scores in rats treated with vehicle or with a ra
ndomly designed oligodeoxynucleotide were not modified. These results
suggest that whereas D1 receptors play a facilitatory role in locomoti
on, D5 receptors exert an inhibitory effect.