ENZYMATIC RESOLUTION OF NEW ANTIINFLAMMATORY DRUG ETODOLAC

Authors
MIZUGUCHI E ITANAMI M ACHIWA K
Citation
E. Mizuguchi et al., ENZYMATIC RESOLUTION OF NEW ANTIINFLAMMATORY DRUG ETODOLAC, Heterocycles, 46, 1997, pp. 149-152
Citations number
9
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
46
Year of publication
1997
Pages
149 - 152
Database
ISI
SICI code
0385-5414(1997)46:<149:ERONAD>2.0.ZU;2-9
Abstract
Optically active etodolac (1) was easily prepared by lipase-catalyzed kinetic resolution. The unnecessary enantiomer as a by-product of the resolution could be racemized and was converted to a repeated substrat e for the enzymatic reaction.