SYNTHETIC APPROACH TOWARD THE DEVELOPMENT OF NEW BETA-LACTAMASE INHIBITORS

Authors
NAGAO Y KUMAGAI T KOBAYASHI S TAMAI S OHTA K INOUE Y KISHI I
Citation
Y. Nagao et al., SYNTHETIC APPROACH TOWARD THE DEVELOPMENT OF NEW BETA-LACTAMASE INHIBITORS, Heterocycles, 46, 1997, pp. 193-198
Citations number
13
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
46
Year of publication
1997
Pages
193 - 198
Database
ISI
SICI code
0385-5414(1997)46:<193:SATTDO>2.0.ZU;2-F
Abstract
New racemic thienamonobactams (21) and (28), designed on the basis of hybridization between thienamycin (5) and aztreonam (6), were successf ully synthesized by exploiting the [2+2] cycloaddition reaction of dik etene with imine (7). Compound (28) exhibited significant inhibitory a ctivity (ID50 = 37 mu M) against Citrobacter freundii cephalosporinase .