SYNTHESIS OF C-RING MODIFIED ANALOGS OF CAMPTOTHECIN

Authors
YONEDA R KIMURA T HARUSAWA S KURIHARA T
Citation
R. Yoneda et al., SYNTHESIS OF C-RING MODIFIED ANALOGS OF CAMPTOTHECIN, Heterocycles, 46, 1997, pp. 357-372
Citations number
16
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
46
Year of publication
1997
Pages
357 - 372
Database
ISI
SICI code
0385-5414(1997)46:<357:SOCMAO>2.0.ZU;2-K
Abstract
Aiming at developing novel antitumor active compounds, we designed hex ahydropyrano[3'', 4''; 3', 4']pyrido[5', 6'; 4, 5]cyclopenta[1, 2-b]qu inoline which is a C-ring modified analogue of camptothecin. The compo unds (9-14) were synthesized via Friedlander condensation and their in vitro cytotoxic activities were tested.