AN EXPEDITIOUS SYNTHESIS OF GEODIAMOLIDE-A, AN 18-MEMBERED CYTOTOXIC DEPSIPEPTIDE FROM MARINE SPONGES

Authors
SHIOIRI T IMAEDA T HAMADA Y
Citation
T. Shioiri et al., AN EXPEDITIOUS SYNTHESIS OF GEODIAMOLIDE-A, AN 18-MEMBERED CYTOTOXIC DEPSIPEPTIDE FROM MARINE SPONGES, Heterocycles, 46, 1997, pp. 421-442
Citations number
36
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
46
Year of publication
1997
Pages
421 - 442
Database
ISI
SICI code
0385-5414(1997)46:<421:AESOGA>2.0.ZU;2-M
Abstract
Geodiamolide A (1) has been efficiently synthesized from the polypropi onate and tripeptide units using the Evans asymmetric alkylation, the Mitsunobu esterification, and the macrolactamization with diphenyl pho sphorazidate (DPPA) as key steps. Efficient esterification between the complex polyketide and tripeptide units was also realized under high pressure conditions.