SYNTHESIS OF HETEROARENECARBONITRILES BY ELECTROPHILIC CYANATION - REACTION OF METALATED HETEROARENES WITH P-TOLUENESULFONYL CYANIDE

Authors
NAGASAKI I SUZUKI Y IWAMOTO K HIGASHIRO T MIYASHITA A
Citation
I. Nagasaki et al., SYNTHESIS OF HETEROARENECARBONITRILES BY ELECTROPHILIC CYANATION - REACTION OF METALATED HETEROARENES WITH P-TOLUENESULFONYL CYANIDE, Heterocycles, 46, 1997, pp. 443-450
Citations number
28
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
46
Year of publication
1997
Pages
443 - 450
Database
ISI
SICI code
0385-5414(1997)46:<443:SOHBEC>2.0.ZU;2-C
Abstract
Several heteroarenecarbonitriles (5) were synthesized in moderate yiel ds from heteroarenes (3) through metalation, followed by electrophilic cyanation using p-toluenesulfonyl cyanide. Similarly, trimethylsilylh eteroarenes (8) were converted to heteroarenecarbonitriles (5) in good yields by treatment with p-toluenesulfonyl cyanide.