A HIGHLY EFFICIENT SYNTHESIS OF 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE, 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE, AND 1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE BY A MODIFIED PUMMERER REACTION
T. Shinohara et al., A HIGHLY EFFICIENT SYNTHESIS OF 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE, 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE, AND 1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE BY A MODIFIED PUMMERER REACTION, Heterocycles, 46, 1997, pp. 555-565
(+/-)-1-Methyl- (13b), (+/-)-1-benzyl- (13c), and (+/-)-1-phenyl- (13d
)-1,2,3,4-tetrahydroisoquinolines, which are supposed to participate i
n the pathogenesis of Parkinson's disease, were prepared by using a mo
dified Pummerer reaction as a key step in excellent overall yields fro
m the commercially available ketones(4b-c).