A HIGHLY EFFICIENT SYNTHESIS OF 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE, 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE, AND 1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE BY A MODIFIED PUMMERER REACTION

Authors
SHINOHARA T TAKEDA A TODA J TERASAWA N SANO T
Citation
T. Shinohara et al., A HIGHLY EFFICIENT SYNTHESIS OF 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE, 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE, AND 1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE BY A MODIFIED PUMMERER REACTION, Heterocycles, 46, 1997, pp. 555-565
Citations number
18
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
46
Year of publication
1997
Pages
555 - 565
Database
ISI
SICI code
0385-5414(1997)46:<555:AHESO1>2.0.ZU;2-K
Abstract
(+/-)-1-Methyl- (13b), (+/-)-1-benzyl- (13c), and (+/-)-1-phenyl- (13d )-1,2,3,4-tetrahydroisoquinolines, which are supposed to participate i n the pathogenesis of Parkinson's disease, were prepared by using a mo dified Pummerer reaction as a key step in excellent overall yields fro m the commercially available ketones(4b-c).