STEREOSELECTIVE SYNTHESIS OF A 2,3-DISUBSTITUTED 5-PYRROLIDINONE DERIVATIVE OF QUINAZOLIN-4(3H)-ONE

Authors
SZABO M KOKOSI J KOVACS A BOCSKEI Z HERMECZ I
Citation
M. Szabo et al., STEREOSELECTIVE SYNTHESIS OF A 2,3-DISUBSTITUTED 5-PYRROLIDINONE DERIVATIVE OF QUINAZOLIN-4(3H)-ONE, Heterocycles, 45(12), 1997, pp. 2437-2442
Citations number
24
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
45
Issue
12
Year of publication
1997
Pages
2437 - 2442
Database
ISI
SICI code
0385-5414(1997)45:12<2437:SSOA25>2.0.ZU;2-A
Abstract
Thermal cyclization of acetoacetamide (3), prepared from 1'-(p-methoxy phenylaminoethyl]quinazolin-4(3H)-one (2) and ethyl acetoacetate, resu lted in the formation of 2-(5-oxopyrrolidin-2-yl)quinazolin-4(3H)-one (6) with high selectivity in excellent yield. The stereostructure of 6 was investigated by NMR spectroscopy, and determined by X-Ray investi gations.