A LYMPHOHISTIOCYTIC VARIANT OF ANAPLASTIC LARGE-CELL LYMPHOMA WITH DEMONSTRATION OF THE T(2-5)(P23-Q35) CHROMOSOME-TRANSLOCATION

Authors
OTT G BASTIAN BC KATZENBERGER T DECOTEAU JF KALLA J ROSENWALD A WEISSINGER F OTT MM KADIN ME MULLERHERMELINK HK
Citation
G. Ott et al., A LYMPHOHISTIOCYTIC VARIANT OF ANAPLASTIC LARGE-CELL LYMPHOMA WITH DEMONSTRATION OF THE T(2-5)(P23-Q35) CHROMOSOME-TRANSLOCATION, British Journal of Haematology, 100(1), 1998, pp. 187-190
Citations number
12
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
100
Issue
1
Year of publication
1998
Pages
187 - 190
Database
ISI
SICI code
0007-1048(1998)100:1<187:ALVOAL>2.0.ZU;2-Y
Abstract
Cytogenetic investigations were performed in a case of a nodal maligna nt non-Hodgkin's lymphoma. Histopathological analysis from an involved lymph node as well as from a skin biopsy revealed a lymphohistiocytic variant of CD30-positive anaplastic large cell lymphoma (ALCL). A t(2 ;5)(p23;q35) chromosome translocation could be observed in all metapha ses analysed. This finding was confirmed both by RT-PCR analysis of th e NPM/ALK fusion protein and by positive staining with the p80(NPM/ALK ) antibody. To the best of our knowledge, this is the first report of a t(2;5) documented by classic cytogenetics in the lymphohistiocytic v ariant of ALCL.