HYPERMETHYLATION OF THE M27-BETA (DXS255) LOCUS IN CHRONIC B-CELL LEUKEMIA

Authors
CROSSEN PE MORRISON MJ
Citation
Pe. Crossen et Mj. Morrison, HYPERMETHYLATION OF THE M27-BETA (DXS255) LOCUS IN CHRONIC B-CELL LEUKEMIA, British Journal of Haematology, 100(1), 1998, pp. 191-193
Citations number
12
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
100
Issue
1
Year of publication
1998
Pages
191 - 193
Database
ISI
SICI code
0007-1048(1998)100:1<191:HOTM(L>2.0.ZU;2-3
Abstract
We have investigated the methylation status of the M27 beta (DXS255) l ocus in 21 female patients with chronic B-cell leukaemia and in 20 nor mal controls. DNA was digested with PstI and then with the methylation sensitive enzyme HpaII and probed with the M27 beta probe. Eight pati ents (38%) showed hypermethylation of the M27 beta locus which was not seen in any of the normal controls. Hypermethylation of the M27 beta locus has also been found in acute myeloid leukaemia, acute lymphocyti c leukaemia and lymphoma, suggesting that hypermethylation of the M27 beta locus is associated with the leukaemic process.