Cmpw. Mandigers et al., ALLOGENEIC BONE-MARROW TRANSPLANTATION WITH T-CELL-DEPLETED MARROW GRAFTS FOR PATIENTS WITH POOR-RISK RELAPSED LOW-GRADE NON-HODGKINS-LYMPHOMA, British Journal of Haematology, 100(1), 1998, pp. 198-206
We present the clinical results of allogeneic bone marrow transplantat
ion (BMT) with T-cell-depleted grafts from HLA-matched sibling donors
in patients with poor-risk relapsed low-grade non-Hodgkin's lymphoma (
NHL). Poor risk was defined as relapse within 12 months after or progr
ession during prior treatment. The conditioning regimen consisted of c
yclophosphamide and total-body irradiation with or without additional
idarubicin. Donor marrow was depleted of T lymphocytes using counterfl
ow centrifugation. Post-BMT prophylaxis of graft-versus-host disease (
GvHD) consisted of cyclosporine A. 15 patients with a median age of 47
years (range 30-57) were transplanted. All patients engrafted. After
a median follow-up of 36 months (range 9-78), 10 patients were alive a
nd in complete remission (CR). Two of them had relapsed after BMT but
re-entered CR following infusions of leucocytes from the original bone
marrow donor. Five patients died; causes of death were cardiomyopathy
(n = 1), chronic GvHD (n = 1) and infection during chronic GvHD (n =
3). We conclude that allogeneic T-cell-depleted bone marrow transplant
ation is an efficacious treatment for patients with poor-risk relapsed
low-grade NHL. Infusions of donor leucocytes reinduced CR in the two
patients with relapse after BMT.