RHABDOMYOLYSIS IN AUTOSOMAL-DOMINANT PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA

Multiple mtDNA deletions have been reported to be a cause of inherited recurrent myoglobinuria. We report a 57-year-old man with autosomal d ominant progressive external ophthalmoplegia and multiple mtDNA deleti ons who developed acute rhabdomyolysis provoked by alcohol. A repeated alcohol intake resulted in a 57-fold increase in serum myoglobin. Pat ients with mitochondrial myopathy and multiple mtDNA deletions, regard less of associated phenotype and mode of inheritance, may develop rhab domyolysis.