COMPARISON OF THE ANTIBACTERIAL ACTIVITIES OF THE QUINOLONES BAY-12-8039, GATIFLOXACIN (AM-1155), TROVAFLOXACIN, CLINAFLOXACIN, LEVOFLOXACIN AND CIPROFLOXACIN

The in-vitro activities of the quinolones Bay 12-8039, gatifloxacin (A M 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin were compared, Gram-positive cocci were most susceptible to Bay 12-803 9, clinafloxacin and trovafloxacin; Enterobacteriaceae and fastidious organisms were most susceptible to ciprofloxacin; Pseudomonas spp, wer e most susceptible to clinafloxacin and ciprofloxacin; anaerobes, Heli cobacter pylori and Campylobacter jejuni were most susceptible to gati floxacin, clinafloxacin and trovafloxacin. Against Gram-positive cocci , the only agents that were more active than ciprofloxacin were those carrying an azabicyclo (trovafloxacin, Bay 12-8039), 3-amino-pyrrolidi nyl (clinafloxacin) or 3-methyl-piperazinyl (gatifloxacin) moiety at p osition C-7.