CHIRAL CAPSULES - 1 - SOFTBALLS WITH ASYMMETRIC SURFACES BIND CAMPHORDERIVATIVES

Molecule-within-molecule complexes are proving ever more useful in phy sical organic chemistry. They provide means of stabilizing reactive in termediates,(1) observing new forms of stereoisomerism,(2) and acceler ating certain reactions.(3) Although a number of chiral cavitands and complexes have been made,(4-8) and guests inside these have been expec ted to experience intensified sensations of asymmetry as a result of c ramped quarters, the stereochemical features in these microenvironment s remain largely unexplored. The possibilities range from asymmetric o uter surfaces through asymmetric cavity Linings to asymmetric cavities . We now have them all in hand and introduce here the initial molecule s with asymmetric surfaces. In the sequel, we will trace the gradual s hift of research focus from the outside to the inside of the self-asse mbling ''softball'' 1.1.