ANALYSIS OF THE SMAD2 GENE IN HEMATOLOGICAL MALIGNANCIES

Authors
IKEZOE T TAKEUCHI S KAMIOKA M DAIBATA M KUBONISHI I TAGUCHI H MIYOSHI I
Citation
T. Ikezoe et al., ANALYSIS OF THE SMAD2 GENE IN HEMATOLOGICAL MALIGNANCIES, Leukemia, 12(1), 1998, pp. 94-95
Citations number
15
Categorie Soggetti
Hematology,Oncology
Journal title
Leukemia → ACNP
ISSN journal
08876924
Volume
12
Issue
1
Year of publication
1998
Pages
94 - 95
Database
ISI
SICI code
0887-6924(1998)12:1<94:AOTSGI>2.0.ZU;2-V
Abstract
A total of 34 leukemia and lymphoma samples (17 clinical samples and 1 7 cell lines) were analyzed for mutations of the Smad2 gene by reverse transcriptase-polymerase chain reaction single strand conformation po lymorphism (RT-PCR-SSCP) analysis. Nine of Phe 34 samples had 18q chro mosomal abnormalities. No shifted bands were detected in any of the he matological malignancies, Our results suggest that resistance Po cell growth inhibitory effects of TGF-beta in hematological malignancies is not due to alterations of the Smad2 gene.