COMPARISON OF USE OF CEREBROSPINAL-FLUID, SERUM, AND THROAT SWAB SPECIMENS IN DIAGNOSIS OF ENTEROVIRAL ACUTE NEUROLOGICAL INFECTION BY A RAPID RNA DETECTION PCR ASSAY

Authors
ANDREOLETTI L BLASSELDAMMAN N DEWILDE A VALLEE L CREMER R HOBER D WATTRE P
Citation
L. Andreoletti et al., COMPARISON OF USE OF CEREBROSPINAL-FLUID, SERUM, AND THROAT SWAB SPECIMENS IN DIAGNOSIS OF ENTEROVIRAL ACUTE NEUROLOGICAL INFECTION BY A RAPID RNA DETECTION PCR ASSAY, Journal of clinical microbiology, 36(2), 1998, pp. 589-591
Citations number
15
Categorie Soggetti
Microbiology
Journal title
Journal of clinical microbiology → ACNP
ISSN journal
00951137
Volume
36
Issue
2
Year of publication
1998
Pages
589 - 591
Database
ISI
SICI code
0095-1137(1998)36:2<589:COUOCS>2.0.ZU;2-U
Abstract
A PCR assay for detection of enterovirus RNA in multiple specimen type s from patients with neurological infections was evaluated. Combined P CR assay of cerebrospinal fluid and serum (systemic specimens) was mor e sensitive than assaying either specimen alone in children but not in adults. Compared with PCR in systemic specimens, detection of enterov irus RNA in throat swabs showed a sensitivity of 62.5% and a specifici ty of 75.6%.