Background Although rare, paralysis secondary to spinal cord ischaemia
after aortic aneurysm surgery is a devastating complication. Many pap
ers have been published on this topic but without a clear consensus on
the best way of minimizing the problem. Recent articles have included
advanced pharmacological approaches and the literature has been revie
wed in light of these. Methods Relevant papers were identified by an e
xtensive text word search of the Medline database and a review of quot
ed articles. Results Spinal cord complications are commoner after the
repair of Crawford type II aneurysms than less extensive aneurysms. Th
e presence of dissection, rupture and prolonged clamp times are associ
ated with an increased incidence. About a quarter of all cord problems
develop over 24 h after surgery and this may be due to a reperfusion
type injury, although the exact mechanisms are by no means clear. Conc
lusion A combination of rapid surgery, left heart bypass for the repai
r of more extensive aneurysms, free spinal drainage and the avoidance
of postoperative hypoxia and hypotension help to minimize spinal cord
ischaemia. No pharmacological agent has yet been shown conclusively to
improve outcome in the clinical setting.