SYNERGISTIC EFFECTS OF TRITERPENIC COMPOUNDS WITH PROSTAGLANDIN-A1 ONVACCINIA VIRUS-INFECTED L929 CELLS

Triterpenic compounds, such as glycyrrhizic acid (GRa) and carbenoxolo ne (CBX), have a synergistic effect with prostaglandin A1 on the inhib ition of vaccinia virus (VV) replication in L929 cells. The fractional inhibitory concentration (FIC) values for GRa and CBX were 0.5 and 0. 25, respectively. In the supernatant of triterpene treated cells, incr eased production of some prostaglandins was shown, whilst cell-associa ted prostaglandins and prostaglandins of the A series were only slight ly influenced by the presence of triterpenes. From these findings ther e is no evidence that prostaglandin production and metabolism could be involved in the antiviral activity of triterpenes. (C) 1997 Elsevier Science B.V.