ONGOING OSTEOLYSIS IN PATIENTS WITH LYMPHANGIOMA

Severe osteolysis is a rare complication of lymphangioma. It can progr ess despite treatment and may be fatal. Four patients presented with m assive osteolysis and serious related complications. Of these, two res ponded well to OK-432 therapy with arrest of the osteolysis. Complete recovery from life-threatening pleural effusion has been noted in one. Of the two nonresponders, one died of progressive osteolysis of the c ervical and occipital bones, the other, despite therapy, still shows p rogressive osteolysis of the left leg from the femur to the phalanges. A boneless leg may be the outcome. Copyright (C) 1998 by W.B. Saunder s Company.