Purpose: The aim of this study was to document the presenting symptoma
tology and radiological findings of failed fundoplication, to determin
e the risk factors involved in recurrent gastro-oesophageal reflux, an
d to assess the results of revisional surgery. Methods: Sixty-six pati
ents requiring redo fundoplication during the past 15 years were studi
ed. Sixty children had their initial fundoplication performed at our i
nstitution. Results: The median time from initial fundoplication to th
e diagnosis of failure was 1.5 years. The main presenting symptoms wer
e severe retching (n = 33), recurrent vomiting and aspiration (n = 26)
and intolerable gas bloat (n = 7). Severe dysphagia occurred in two c
hildren with light Nissen fundoplications. Contrast radiographic studi
es demonstrated fundoplication failure and correlated with the operati
ve findings in 85% of cases. Risk factors for failure comprised hypert
onic cerebral palsy, severe learning difficulties, oesophageal atresia
, CHARGE syndrome, and tracheomalacia. The cause for the fundoplicatio
n failure included herniation of the fundoplication into the posterior
mediastinum (failed crural repair, n = 30), disruption of the wrap (n
= 10), combination of herniation and disruption (n = 22), and a tight
wrap (n = 4). After revisional surgery, 13 children had persisting sy
mptoms, five of whom underwent a third antireflux procedure. Conclusio
ns: The predominant cause of fundoplication failure is herniation into
the posterior mediastinum, which occurred most frequently in children
with hypertonic cerebral palsy. This may be prevented by meticulous a
ttention to accurate apposition of the crura at initial procedure. Red
o fundoplication failed to resolve the preoperative symptoms in 20%, w
ith five children requiring a third fundoplication. Copyright (C) 1998
by W.B. Saunders Company.