REGRESSION OF UTERINE LOW-GRADE SMOOTH-MUSCLE TUMORS METASTATIC TO THE LUNG AFTER OOPHORECTOMY

Background: Metastatic uterine low-grade smooth-muscle tumors may pres ent with pulmonary symptoms and radiographic lung abnormalities consis tent with metastatic neoplasms. Ovarian hormone stimulation of these s mooth-muscle tumors has been suggested, but the role of surgical or me dical oophorectomy has not been established in patients with metastati c disease. Cases: Two women with histologically confirmed uterine low- grade smooth-muscle tumors metastatic to the lung had progressive and complete tumor regression after oophorectomy and no further therapy. C onclusion: Some uterine low-grade smooth-muscle tumors metastatic to t he lung regress after oophorectomy. Removing ovarian hormone stimulati on may result in complete tumor regression without the need for furthe r therapy. (C) 1997 by The American College of Obstetricians and Gynec ologists.