S. Belikov et al., SEQUENTIAL ARRANGEMENT, NOT TRANSCRIPTIONAL ACTIVITY, DETERMINES CONFORMATIONAL STABILITY OF NUCLEOSOMES, Journal of biomolecular structure & dynamics, 14(5), 1997, pp. 651-655
Gel electrophoresis in urea gradient was applied to study the unfoldin
g effect of increasing concentrations of urea on the nucleosome struct
ure. We showed that conformational stability of nucleosomes is determi
ned by nucleotide sequence but not by transcriptional activity of DNA
in chromatin.