LOCALIZATION OF SH-PTP1 TO SYNAPTIC VESICLES - A POSSIBLE ROLE IN NEUROTRANSMISSION

Authors
JENA BP WEBSTER P GEIBEL JP VANDENPOL AN SRITHARAN KC
Citation
Bp. Jena et al., LOCALIZATION OF SH-PTP1 TO SYNAPTIC VESICLES - A POSSIBLE ROLE IN NEUROTRANSMISSION, Cell biology international, 21(8), 1997, pp. 469-476
Citations number
25
Journal title
Cell biology international → ACNP
ISSN journal
10656995
Volume
21
Issue
8
Year of publication
1997
Pages
469 - 476
Database
ISI
SICI code
1065-6995(1997)21:8<469:LOSTSV>2.0.ZU;2-W
Abstract
The tyrosine kinase pp60(src) is known to phosphorylate synaptophysin and in doing so may regulate neurotransmitter release. The tyrosyl pho sphorylated state of synaptophysin is dependent on pp60(src) kinase an d the unknown protein tyrosine phosphate phosphohydrolase (PTPase, EC 3.1.3.48). Here we report the protein tyrosine phosphate phosphohydrol ase SH-PTP1, to associate with synaptic vesicles and interact with syn aptophysin. These studies identify SH-PTP1 as a new member of the secr etory machinery at the nerve terminal and suggest its involvement in n eurotransmission. (C) 1997 Academic Press Limited.