TUNING GLYCOSIDE REACTIVITY - NEW TOOL FOR EFFICIENT OLIGOSACCHARIDE SYNTHESIS

The concise preparation of complex oligosaccharides remains a signific ant challenge for synthetic organic chemistry. The tuning of donor rea ctivity during coupling reactions, such that we may avoid the lengthy protecting-group manipulations of classical carbohydrate synthesis, af fords a strategy for the rapid assembly of large sugar systems. Compet ition reactions have been used to quantify the influence of protecting groups, monosaccharide type, and anomeric leaving groups on the react ivity of various glycosyl donors.