DEVELOPMENT OF A MODIFIED BETA-CYCLODEXTRIN BASED FLUOROSENSOR FOR DIPYRIDAMOLE

2,6-O-diethyl-beta-cyclodextrins were prepared and immobilized onto si lica gel to develop a fluorosensor for dipyridamole. The analytical pe rformance characteristics of the proposed sensor for analysis of dipyr idamole were as follows: the detection limit was 0.8 nmol/L with a rel ative standard deviation of 1.4% for 10 determinations of 50 nmol/L of dipyridamole. The modification of beta-CD improved the sensitivity an d selectivity for measuring dipyridamole. The recommended method has b een successfully tested for the determination of dipyridamole in clini cal samples (urine and pharmaceutical preparations).