MOLECULAR MODELING AND BIOLOGICAL EVALUATION OF A SERIES OF HYDROXYLATED BENZYLIDENEANILINES AND BENZYLAMINES DESIGNED AS TYROSINE KINASE INHIBITORS

Authors
SOLOMONS KRH LIEBERMAN HF GROUNDWATER PW HIBBS DE HURSTHOUSE MB
Citation
Krh. Solomons et al., MOLECULAR MODELING AND BIOLOGICAL EVALUATION OF A SERIES OF HYDROXYLATED BENZYLIDENEANILINES AND BENZYLAMINES DESIGNED AS TYROSINE KINASE INHIBITORS, Anti-cancer drug design, 12(8), 1997, pp. 635-647
Citations number
29
Categorie Soggetti
Pharmacology & Pharmacy",Oncology,Biology,"Chemistry Medicinal
Journal title
Anti-cancer drug design → ACNP
ISSN journal
02669536
Volume
12
Issue
8
Year of publication
1997
Pages
635 - 647
Database
ISI
SICI code
0266-9536(1997)12:8<635:MMABEO>2.0.ZU;2-D
Abstract
A series of hydroxylated benzylideneanilines and benzylamines were pre pared and tested for inhibition of epidermal growth factor receptor-as sociated protein tyrosine kinase (PTK) activity in vitro. Molecular mo delling and analysis of the biological results lead us to propose a mi nimal structural pharmacophore for two distinct binding sites within t he PTK domain.