DETERMINATION OF COAGULATION INHIBITOR LEVELS AND RESISTANCE TO ACTIVATED PROTEIN-C IN PATIENTS UNDERGOING GASTRIC-SURGERY FOR BENIGN AND MALIGNANT DISORDERS
Bs. Andersen et al., DETERMINATION OF COAGULATION INHIBITOR LEVELS AND RESISTANCE TO ACTIVATED PROTEIN-C IN PATIENTS UNDERGOING GASTRIC-SURGERY FOR BENIGN AND MALIGNANT DISORDERS, Haemostasis, 27(4), 1997, pp. 157-162
The aim of the present study was to determine plasma levels of protein
C antigen (PC:Ag) and activity (PC:Act), tissue factor pathway inhibi
tor (TFPI), protein S (PS), antithrombin (AT), heparin cofactor II (HC
II), and resistance to activated protein C (APCR) before, during and a
fter elective gastric surgery in order to compare patients with and wi
thout gastric malignancy. Blood was collected from a forearm vein of t
wo age-matched patient groups undergoing elective gastric surgery, 9 p
atients with and 9 patients without gastric malignancy. The plasma lev
els of the parameters were determined preoperatively, intraoperatively
, and on days 1 and 7 postoperatively. On the Ist and 7th postoperativ
e day, plasma levels of HCII were significantly lower in patients oper
ated for gastric malignancy than in those operated for benign disorder
s, but levels of TFPI, PC:Act, PC:Ag, AT, PS and APCR did not differ i
n the postoperative period. The day-to-day variation was also rather s
imilar in the two patient groups.