The use of tea is derived from the Far East and was introduced into Eu
rope, where in some countries tea soon became a favorite drink. Tea ac
counts for about 43% of all caffeine consumption. Total world caffeine
consumption in 1981 was estimated to be approximately 120,000 tons, e
quivalent to 70 mg a day for each human. There is evidence from in vit
ro and animal studies, as well as from human investigations, that tea
and its main constituents can prevent atherosclerosis to a certain ext
ent. Supplementing tea as beverage instead of coffee might react benef
icially with other antiatherosclerotic strategies. Investigations on t
he hypolipidemic and antiatherosclerotic action of tea, and therefore
flavonoid intake, are still in their infancy and further fundamental d
ata from controlled trials are needed to evaluate possible positive ef
fects of tea consumption to prevent or treat atherosclerosis. Brief in
formation on the biological potential of caffeine and flavonoids, as w
ell as on their possible beneficial effects on the atherosclerotic pro
cess is documented in this review.