BACKGROUND AND OBJECTIVE: Iris neovascularization used to be considere
d a strict contraindication to intraocular surgery, especially intraoc
ular lens implantation. In this study, the authors analyzed whether ca
taract extraction and posterior chamber lens implantation is associate
d with unacceptable intraoperative and early postoperative complicatio
ns in patients with proliferative diabetic retinopathy and rubeosis ir
idis. PATIENTS AND METHODS: Using a computerized data retrieval system
, the authors identified all the patients with manifest iris neovascul
arization and proliferative diabetic retinopathy who underwent catarac
t extraction in their institution between 1989 and 1995. The preoperat
ive, intraoperative, and early postoperative data were analyzed retros
pectively with regard to complications and visual results. RESULTS: Th
irty-nine eyes of 33 patients (mean age 64.6 +/- 10.9 years) with mani
fest pupillary rubeosis iridis were analyzed. All but 3 of the eyes ha
d undergone previous retinal laser treatment, with dense cataracts pre
venting additional photocoagulation. Additional chamber angle neovascu
larization was present in 11 eyes. Posterior chamber intraocular lense
s were implanted in 35 eyes. Intraoperatively, iris hemorrhage was not
ed in 10 eyes and was significantly more frequent in eyes that underwe
nt nuclear expression (50%) than in those that underwent phacoemulsifi
cation (12%; P = .019). Postoperatively, spontaneously resolving hyphe
ma was observed in 7 eyes as well as reversible fibrin formation in 6
eyes. No severe sight-threatening complications occurred. Visual acuit
y improved in 33 (85%) of the eyes. CONCLUSION: Cataract extraction wi
th posterior chamber lens implantation does not appear to be associate
d with unacceptable intraoperative or early postoperative complication
s. However, adequate treatment of underlying diabetic retinopathy prio
r to cataract extraction (and if necessary, postoperatively) is essent
ial to prevent the progression of retinal and iris neovascularization.